WuXi Biologics
Offering End-to-End Solutions
Research Chemistry
Services
Targeted Protein Degrader
Synthesis, Analysis, Purification and DMPK
- We have 1,100+ chemists with considerable experiences in the linkers, E3 ligase ligand and target protein ligand synthesis since 2016
- >180 clients/collaborations
- >238,000 compounds synthesized and >1,000 diverse linkers synthesized
- Experienced in versatile linkers synthesis, 100+ are readily available
- Novel linker synthesis by high productivity, quality, speed, and reliability
- Experienced in CRBN/VHL/IAP/MDM2 and novel E3 ligase ligands synthesis, >30 CRBN/VHL ligands are readily available
- >60 series of target protein ligands pre-coupled with various linkers
- >200 methods of Prep-HPLC and chiral-SFC for purification
- Efficient in-vitro/in-vivo testing by WuXi DMPK
- Innovative online dilution system designed for Targeted Protein Degrader
- Native-MS analysis for ternary complex confirmation
- Proteomics studies to identify off-target effect
Well-established Modular System
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- A modular platform: More efficient Targeted Protein Degrader synthesis
Linkers: >1,000 most frequently used linkers, e.g. PEG, alkyl, ”clickable”, rigid, etc. are readily available from WuXi AppTec LabNetwork (www.LabNetwork.com)
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- Customized Targeted Protein Degrader: From mg to kg scale
E3 ligase ligands: >200 common ligands, e.g. VHL, CRBN, etc. are readily available from WuXi AppTec LabNetwork (www.LabNetwork.com)
TPD Drug Discovery using MS Technique
