Macrocyclic Chemistry

Capability of Macrocyclic Compounds Platform

Rich experience (>16 years) on the construction of versatile macrocyclic compounds, more than 10 representative cyclization methods have been developed Macrocyclic compounds such as lactams, lactones, sulfonamides, ethers, bi-cyclic & tri-cyclic, etc. can be efficiently synthesized, more than 2000 macrocyclic compounds have been prepared and >50 g of desired products with 20-31 steps have been obtained

>2000 Macrocyclic compounds synthesized

>10 Supported candidates

>50 Grams scaled up 20- 31 steps

>18 Years experiences

>10 Represen-tative cyclization methods

• Mitsunobu Cyclization
• RCM Cyclization
• Sulfonamide Formation
• Lactam Cyclization
• Substitution Cyclization
• Click Reaction
• Reductive Amination
• C-H Activation
• Disulfide Bond Formation