WuXi Biologics
Offering End-to-End Solutions
Research Chemistry
Services
Library
Library Overview
- Over 20 years of providing high-quality services in combinatorial chemistry and small molecule library design and synthesis, with more than 3 million compounds delivered to support drug discovery and agricultural/crop science projects worldwide
- Offering world-class design and synthesis of all library types at competitive prices, including parallel medicinal chemistry libraries, library enrichment projects, focused/targeted libraries and virtual space
- Streamlined processes to ensure rapid library production, with whole library delivery as quick as 7 calendar days from project initiation
- Exceeding clients’ expectation through strict, multi-level quality control procedures. Each compound undergoes LCMS and/or 1H NMR analysis before delivery
- Significant investment in our in-house reaction condition screening platform to speed up problem solving and increase success rate
- Applying cutting-edge chemistry techniques, such as photoredox-chemistry, electro-chemistry etc, to enable finalizing libraries with up to a 100% success rate
- Over 50,000 reagents and 15,000 unique scaffolds/building blocks in stock to enhance library design with novelty and diversity, and expedite production with materials ready for bench chemists within 24 h
-
Design
-
Synthesis
-
Delivery
-
Phase1 BB Docking
50M Virtual compounds- >90K Building blocks
- > 40 Reactions
- >120 Protocols
- ~75% Success rate
- Deliver in 4-6 weeks
-
Phase2 WuXi Unique Template
9B Virtual compounds- WuXi unique template&building blocks
- More reaction types
- More protocols
- ~75% Success rate
- Deliver in 6-8 weeks
-
Phase3 Drug-like Core
8.2B Virtual compounds- Design drug-like core
- More building blocks
- Docking with protein
- ~75% Success rate
- Deliver in 6-8 weeks
Parallel Medicinal Chemistry (PMC)
The art and science of combinatorial chemistry has undergone paradigm shifts, from the initial on large combinatorial matrix to small, focused libraries supporting medchem research, e.g. Parallel Medicinal Chemistry (PMC). After 17+ years continuous improvement on innovative capabilities and workflow optimization, WuXi PMC library service is more efficient by an order of magnitude in terms of speed and successful rate.
- 20 to 200 compounds/library vs traditional thousand of cpompounds/library
- High speed: Short cycle time (2~3 weeks)
- High efficiency: 85% average success rate
- 46+ reaction types, 30+ ring formation reactions, ~1,000 parallel reaction protocols
- 100,000+ Items in monomer performance database
Off-The-Shelf (OTS) Library
WuXi Chemistry Research Chemistry Services provides library service for more than 20 years. We have ~200K sample delivered/year. The cycle time could be shortened to 1-2 days. Our Off-The-Shelf (OTS) library has more than 130K solids and solutions in stock with >95% Lipinski RO5 and >99% novelty.
Profiles
Diversity
- Bemis-Murcko framework
- Cover 10,353 frameworks
- Size range for each framework: 1 – 1,362 compounds
- Average size for each framework: 11.3 compounds
- The 79 most frequently (>0.2%) occurring frameworks account for only 24% of the whole database
Sample 116,540 compounds
