WuXi Biologics
Offering End-to-End Solutions
Research Chemistry
Services
Stable Isotope Labeling Chemistry
Overview
- Strong experience in non-radioactive isotopic labeling chemistry with D, 13C and 15N
- Rich experience in target design, synthesis and qualification
- Combining WuXi AppTec’s rich chemistry experience with isotope labeling proficiency
- Service includes custom synthesis of stable isotope labeled target, small molecule inventory of isotope labeled starting materials and intermediates
- Accomplished more than 100 stable isotopic labeled projects in the past two years
- >1,000 Labeled compounds delivered
- Stocking 200+ labeled raw materials and building blocks to support quick delivery
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Labeling Design
- Isotope selection
- Position selection
- >=3 (D / 13C / 15N)
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Route Validation
- Route design
- Advanced intermediates
- Incorporation of isotope at the final step
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Labeling Synthesis
- Isotope synthesis
- Ensuring no D-H exchange
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Material Release
- NMR to identify structure
- HRMS for determining isotope %
- HPLC for purity assessment