Reaction Condition Screening

Overview

We have proven adept at processing challenging structures, removing synthesis roadblocks, increasing yield and process efficiency.

• Internal support and custom research services in reaction condition screening and optimization
• >230,000 screened conditions for medicinal chemistry and process chemistry
• 3,500+ problem solving cases achieved in 2022
• 70% Success rate on failed reactions from bench chemists
• Large catalyst/ligand collection and reaction condition coverage, minimal starting material requirement and short turnaround time
• Rich experience in a variety of reaction condition screenings including catalysis/ligand screening, base/acid/solvent screening, hydrogenation screening (including asymmetric hydrogenation and heterogeneous hydrogenation catalyst), chiral resolution method development, salt formation purification method development and recrystallization method development
• High throughput experimentation service with fast LCMS data analysis
• Customized catalysis services including customized screening templates, catalyst/ligand synthesis, focused library synthesis and screening
• >100 metal catalysts in inventory, 40+ reaction types, and 50+ sophisticated condition templates ready for condition screening
• Automated catalyst kit sample preparation by liquid handler and build-in automated micro liquid workup station for LCMS sample preparation