WuXi Biologics
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Flow Chemistry
Flow Chemistry – the better solution for safety/scale up/efficiency
Since 2015, our Flow Chemistry team has provided condition screening and scale-up services for 100+ customers globally. Our aim is to run in a continuous flow stream to provide faster, cleaner and safer reactions by integrated synthesis, work-up, and analysis.
Flow Chemistry Service Highlights
- Dedicated flow chemistry teams at 5 domestic sites
- Technical unit of catalyst development for hydrogenation in flow
- Technical unit of engineering
- Full experience from parameter optimization to reaction up-scaling
- Daily support to all FTE and FFS projects
- 65,000+ reactions finished by 2024-Q3
- >95% success rate
- Experience with a wide scale of reactions from mg to kg
- 1-2 days of cycle time for product delivery in early phase
- Seamless transfer to late phase development and manufacturing
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Reaction Types
- Photochemistry
- Hydrogenation
- Metalation
- Nitration
- Diazotization
- Oxidation
- Reduction
- High temperature
- Cross-coupling
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Instruments
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Vapourtec flow system R series
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- Flexible, precise and automatable
- Best in class performance
- Ideal for Medchem and process research
- Easy to set up and use
- Versatile and robust pumps
- Wide range of reaction conditions possible
- Cited in over 600 peer reviewed publications
- A proven design with over 400 installations worldwide
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Corning flow system
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- 1~5 kg production per day
- Outstanding mixing and heat exchange
- Low internal volume
- High residence time
- High chemical durability
- Flow rate range of 5 mL/min to 50 mL/min
- Broad temperature range, from -60 to 200 ℃
- Pressure up to 1.8 Mpa
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Oushisheng flow hydrogenation system
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- 2~5 kg production per day
- Broad temperature range, from r.t. to 200 ℃
- Catalyst diameter, from 0.2-2 mm
- Flow rate range of 5 mL/min to 50 mL/min
- Pressure up to 10 MPa
Flow Chemistry Service from Condition Screening to Scale Up
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Condition Screening
- Photo reactor
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Development
- Vapourtec flow reactor
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Scale up
- 365-850 nm LED flow reactor