WuXi Biologics
Offering End-to-End Solutions
Research Chemistry
Services
Targeted Protein Degrader
Synthesis, Analysis, Purification and DMPK
- Over 1,000 chemists with extensive experience in synthesizing linkers, E3 ligase ligands, and target protein ligands since 2016
- Engaged with >150 clients/collaborations
- Synthesized >158,000 compounds and >1,000 diverse linkers
- Expertise in synthesizing versatile linkers with 100+ readily available
- Novel linker synthesis with high productivity, quality, speed, and reliability
- Deep experience in CRBN/VHL/IAP/MDM2 and other novel E3 ligase ligand synthesis, with >30 CRBN/VHL ligands readily available
- >60 series of target protein ligands pre-coupled with various linkers
- More than 200 methods of prep-HPLC and chiral-SFC for analysis and purification
- Comprehensive in-vitro/in-vivo testing by the WuXi DMPK team
- Innovative online dilution system designed for Targeted Protein Degraders
- Native-MS analysis for ternary complex confirmation
- Proteomics studies to identify off-target effects
Well-established Modular System
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- A modular platform: More efficient Targeted Protein Degrader synthesis
- Customized Targeted Protein Degrader: From mg scale to kg scale
Linkers: Most frequently used linkers, e.g. PEG, alkyl, ”clickable”, and rigid linkers
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- In-stock compounds: More than 200 in-stock linkers or E3 ligase ligands based on literatures
E3 ligase ligands: More than 150 common ligands are readily available, e.g. VHL, CRBN, cIAP
TPD Drug Discovery using MS Technique
