Macrocyclic Chemistry

Overview

We have rich experience in constructing versatile macrocyclic compounds and have applied more than 10 representative cyclization methods. Our expertise allows efficient synthesis of macrocyclic compounds such as lactams, lactones, sulfonamides, ethers, bi-cyclic and tri-cyclic structures. More than 2,000 macrocyclic compounds have been prepared and >50 g of desired products with 20-31 steps synthesis have been obtained.

>16 Years of experience

>2,000 Macrocyclic compounds synthesized

>50 Grams scale-up in 20-31 steps synthesis

>10 Representative cyclization methods

• Mitsunobu Cyclization
• RCM Cyclization
• Sulfonamide Formation
• Lactam Cyclization
• Substitution Cyclization
• Click Reaction
• Reductive Amination
• C-H Activation
• Disulfide Bond Formation
• And more