WuXi Biologics
Offering End-to-End Solutions
Research Chemistry
Services
Library
Library Overview
- Over 20 years of providing high-quality services in combinatorial chemistry and small molecule library design and synthesis, with more than 3 million compounds delivered to support drug discovery and agricultural/crop science projects worldwide
- Offering world-class design and synthesis of all library types at competitive prices, including parallel medicinal chemistry libraries, library enrichment projects, focused/targeted libraries and virtual libraries
- Streamlined processes to ensure rapid library production, with whole library delivery as quick as 7 calendar days from project initiation
- Exceeding clients’ expectation through strict, multi-level quality control procedures. Each compound undergoes LCMS and/or 1H NMR analysis before delivery
- Significant investment in our in-house reaction condition screening platform to speed up problem solving and increase success rate
- Applying cutting-edge chemistry techniques, such as photoredox-chemistry, electro-chemistry etc, to enable finalizing libraries with up to a 100% success rate
- Over 50,000 reagents and 15,000 unique scaffolds/building blocks in stock to enhance library design with novelty and diversity, and expedite production with materials ready for bench chemists within 24 h
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Design
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Synthesis
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Delivery
WuXi Virtual Library
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Phase1 BB Docking
50M virtual compounds- >90K Building blocks
- > 40 Reactions
- >120 Protocols
- ~75% Success rate
- Deliver in 4-6 weeks
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Phase2 WuXi Unique Template
9B virtual compounds- WuXi unique template&building blocks
- More reaction types
- More protocol
- ~75% Success rate
- Deliver in 6-8 weeks
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Phase3 Drug-like Core
8.2B virtual compounds- Design drug-like core
- More building blocks
- Docking with protein
- ~75% Success rate
- Deliver in 6-8 weeks
Parallel Medicinal Chemistry (PMC)
The art and science of combinatorial chemistry has undergone paradigm shifts, moving from large combinatorial matrix to small, focused libraries that support medicinal chemistry research, such as Parallel Medicinal Chemistry (PMC). Compared with traditional screening library synthesis, WuXi PMC library service offers vastly superior speed and success rate.
- 20 to 200 compounds per library, vs traditional thousands of compounds per library
- High speed: Short cycle time (2~3 weeks)
- High efficiency: 85% average success rate
- 46+ reaction types, 30+ ring formation reactions, ~1,000 parallel reaction protocols
- 100,000+ items in the monomer performance database
Off-The-Shelf (OTS) Library
WuXi Chemistry Research Chemistry Services has provided library service for more than 20 years, delivering approximately 200,000 samples per year. Our streamlined process can shorten the cycle time to just 1 – 2 days. Our Off-The-Shelf (OTS) library boasts over 130,000 solids and solutions in stock, with >95% Lipinski RO5 and >99% novelty.
Profiles
Diversity
- Bemis-Murcko framework
- Cover 10,353 frameworks
- Size range for each framework: 1 – 1,362 compounds
- Average size for each framework: 11.3 compounds
- The 79 most frequently (>0.2%) occurring frameworks account for only 24% of the whole database
Sample 116,540 compounds
